美金刚联合奥氮平治疗伴发精神行为症状的老年痴呆临床研究

摘要

目的 观察美金刚联合奥氮平治疗伴发精神行为症状的老年痴呆患者的临床疗效与安全性.方法 选取医院2014年收治的老年痴呆伴精神行为障碍住院患者120例,随机分为美金刚组(A组)、奥氮平组(B组)和美金刚联合奥氮平组(C组),各40例.治疗前和治疗后的第2,4,8,12周,分别以蒙特利尔认知评估量表(MOCA)、痴呆病理行为评定量表(BEHAVE-AD)评价疗效,副反应量表(TESS)评定药品不良反应.结果 治疗后,3组患者BEHAVE-AD评分比较,C组明显优于A组和B组(P<0.05);MOCA评分,A组及C组均显著提高(P<0.05);不良反应发生率,A组及C组均明显低于B组(P<0.05).结论 美金刚联合奥氮平能快速、有效控制老年痴呆患者的精神行为症状,改善患者认知功能,且不良反应小,值得临床推广.%Objective To study the clinical treatment strategy plan and clinical efficacy of memantine combined with olanzapine for treating behavioral and psychological symptoms in elderly patient with dementia. Methods 120 senile dementia cases of hospitalized patients with behavioral and psychological symptoms were selected and randomly divided into 3 groups,the memantine treatment group(group A),olanzapine treatment group (group B),and the memantine combined with olanzapine treatment group (group C),40 cases in each group. Before and after treatment of 2,4,8,12 weeks,MOCA and BEHAVE -AD scales were used to evaluate curative effect, TESS scales to evaluate drug adverse reactions. Results After treatment,compared with group A and B,group C had significant better results in BEHAVE-AD scale (P < 0. 05). When comparing the MOCA scale after treatment,group A and C had more improvement (P < 0. 05). The incidence of adverse reactions in group A and C was significantly lower than that in group B(P < 0. 05). Conclusion Memantine combined with olanzapine can quickly and effectively control the behavioral and psychological symptoms of dementia,improve cognitive function and have less adverse reaction.