白蛋白联合蓝光光疗对新生儿黄疸的临床疗效及血清学指标影响

摘要

目的 探讨白蛋白联合蓝光光疗对新生儿黄疸临床疗效及血清学指标的影响.方法 随机选取医院儿科2014年5月至2016年5月收治的新生儿黄疸患儿80例,按随机数字表法分为研究组和对照组,各40例.在常规治疗基础上,对照组患儿仅采用蓝光光疗治疗,研究组患儿采用白蛋白联合蓝光光疗.结果 研究组患儿治疗的总有效率为97.50％(39/40),显著高于对照组的77.50％(31/40,P<0.05);与治疗前比较,两组患儿的血清总胆红素(TBIL)、超敏C反应蛋白(hs-CRP)、总胆汁酸(TBA)、碱性磷酸酶(AKP)、γ-谷氨酰基转移酶(γ-GT)、游离脂肪酸(FFA)等血清学指标水平均显著降低(P<0.05),且研究组患儿比对照组患儿降低更明显(P<0.05).结论 白蛋白联合蓝光光疗能有效提高新生儿黄疸的疗效,改善患儿的血清学指标.%Objective To investigate the clinical effect of albumin combined with blue light therapy in treating neonatal jaundice and its effect on serological indexes. Methods Totally 80 neonates with neonatal jaundice admitted to pediatric of our hospital from May 2014 to May 2016 were randomly selected and divided into the study group and the control group according to the random number table method, 40 cases in each group. On the basis of routine treatment, the control group was only given blue light therapy, while the study group was given albumin combined with blue light therapy. Results The total effective rate of the study group was 97. 50％( 39/40 ) , which was significantly higher than 77. 50％ ( 31/40 ) of the control group ( P < 0. 05 ) ) . Compared with before treatment, the levels of serum total bilirubin ( TBIL ) , high sensitive C-reactive protein ( hs-CRP ) , total bile acid ( TBA ) , alkaline phosphatase ( AKP ) ,γ- glutamyltransferase (γ-GT ) , free fatty acid ( FFA ) in the two groups after treatment were significantly lower ( P < 0. 05 ) , and those in the study group were significantly lower than those in the control group ( P < 0. 05 ) . Conclusion Albumin combined with blue light therapy in treating neonatal jaundice can effectively improve the total curative effect and serological indexes.