标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能的影响

摘要

Objective To explore the influence of specific immunotherapy on house dust mite specific IgG4 and pul-monary function of asthmatic children. Methods 68 children with asthma from June 2012 to June 2013 in our hospital were selected and randomly divided into the experimental group and the control group,34 cases in each group.The ex-perimental group was given specific immunotherapy,the control group was given inhaled corticosteroids.Then house dust mite specific IgG4 and pulmonary function in two groups was compared. Results The level of FEV1,PEF in the experi-mental group was higher than that in the control group,with significant difference (P<0.05).The level of IgG4 after treat-ment in the experimental group was higher than the control group,with significant difference (P<0.05). Conclusion Specific immunotherapy has significant impact on house dust mite specific IgG4 and pulmonary function of asthmatic children,and clinical should cause enough attention.%目的：探讨标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能的影响。方法选取本院2012年6月~2013年6月收治的68例哮喘患儿作为研究对象，随机分成实验组和对照组，各34例。实验组给予标准化免疫治疗，对照组给予单纯吸入性糖皮质激素治疗。比较两组的屋尘螨特异性IgG4及肺功能改善情况。结果实验组的FEV1、PEF水平显著高于对照组，差异有统计学意义(P<0.05)。实验组治疗后的IgG4水平显著高于对照组，差异有统计学意义(P<0.05)。结论标准化免疫治疗对哮喘儿童屋尘螨特异性IgG4和肺功能具有十分重要的影响，临床应引起足够重视。