目的：探讨氯沙坦对老年冠心病患者内皮祖细胞(EPCs)的动员作用及改善血管内皮功能的机制。方法选取老年冠心病患者65例，随机分为对照组32例和观察组33例，分别给予常规药物和常规药物+氯沙坦治疗，检测治疗前后血EPCs及NO和内皮素-1(ET-1)。结果治疗后观察组EPCs及NO水平高于对照组(P<0.05)，耘栽-1明显低于对照组(P<0.01)。观察组氯沙坦治疗后EPCs与NO呈现正相关(r=0.421, P=0.014),与ET-1呈现负相关(r=-0.398, P=0.021)。结论氯沙坦能够改善老年冠心病患者内皮功能，其作用机制可能是通过对EPCs的动员作用而发挥功能。%Objective To study effects of losartan on the mobilization of EPCs and its mechanism of improving endothe-lial function in elderly patients with coronary heart disease. Methods A total of 65 elderly patients with coronary heart disease were randomly divided into control group (32 cases) and observation group (33 cases), the former were given con-ventional medicine and the latter conventional medicine with losartan. The EPCs , NO and endothelin-1(ET-1) were detected before and after treatment. Results There was no difference between the two groups before treatment in gener-al information (P<0.05); After treatment, EPCs and NO in observation group were statistically higher than that in the control group(P<0.05), but ET-1 was significantly lower than the control group(P<0.01). EPCs and NO were positively correlated in observation group(r=0.421, P=0.014);EPCs and ET-1 showed a significant negative correlation (r=-0.398, P=0.021). Conclusion Losartan can improve the function of vascular endothelial in elderly patients with coronary heart disease, and it may be achieve this goal through the mobilization of EPCs.
展开▼
