格林-巴利综合征患者急性期病情严重程度及相关因素分析

摘要

Objective To explore syndrome of acute stage in patients with the severity of the disease and the related factors of green-barre. Methods 49 cases in our hospital for treatment of patients with GBS from May 2010 to May 2013 were collected. The disease grade according to Hughes score were divided, according to the age of onset is more than 40 years, the existence of the medulla oblongata and autonomic symptoms, disease is the most serious double upper limb muscle strength sum is≤5, double upper limbs F wave rate≤50%indicators to assess. Results Comparison of Hughes score group, the peak incidence of<14d and diarrhea, compared the two groups, the difference was not statistically significant (P > 0.05). And older than 40 years old, bulbar dysfunction, autonomic dysfunction, double upper limb muscle strength sum ≤ 5, F ≤ 50% wave frequency, the comparison between two groups, the difference was statistically significant (P < 0.05). Application of Logistic regression multivariate analysis indicated that, the factors of the GBS patients with acute phase of the illness can develop to severe, bulbar dysfunction, autonomic dysfunction and double upper limb muscle strength sum (P<0.05);but not related with age above 40 years old (P>0.05). Conclusion Patients with GBS of upper limb muscle strength difference, autonomic dysfunction is relatively heavy.%目的探讨格林-巴利综合征患者急性期病情严重程度及相关因素的关系。方法对选取2010年5月～2013年5月在本院治疗的GBS患者49例，病情等级根据Hughes评分划分，针对患者发病年龄是否大于40岁、是否存在延髓及自主神经症状、病情最重时双上肢近端肌力总和是否≤5分、双上肢F波出现率是否≤50%等指标进行评估。结果Hughes评分分组比较中，发病高峰期＜14d及腹泻，两组比较，差异无统计学意义（P＞0.05）；而年龄＞40岁，延髓功能障碍，植物神经功能障碍，双上肢近端肌力总和≤5，F波的出现频率≤50%，两组间比较，差异有统计学意义（P＜0.05）。延髓功能障碍，植物神经功能障碍及双上肢近端肌力总和为GBS患者急性期病情可发展至重症的相关因素（P＜0.05）；而与年龄＞40岁不相关（P＞0.05）。结论存在双上肢近端肌力差、自主神经功能障碍的GBS患者病情相对较重。