细胞周期蛋白激酶抑制剂研究现状

摘要

As normally accepted, the cell proliferation is regulated through cell cycle and the occurrence of tumor may lie in deregulation of cell cycle, directly resulted from the abnormal of the complex of cyclin dependent kinase(CDK).It has become one of the most effective strategies to inhibit the activity of the complex for dealing with tumors.Thus,the study on CDK/Cylclin complex inhibitors is one of hot focuses in antitumor drug discovery.This thesis mainly discusses the types of CDK/Cyclin inhibitors and their clinical issues.%目前普遍观点认为，肿瘤产生的本质是细胞增殖的调节失控，而细胞的增殖要通过细胞周期来调控。细胞周期调控激酶复合物[cyclin dependent kinase（CDK）/Cyclin]活性的异常是导致细胞周期失控的根本原因。抑制CDK/Cyclin激酶的活性成为有效治疗肿瘤的策略之一。因此，针对CDK/Cyclin激酶抑制剂的研究是当前抗肿瘤药物开发的热点之一。本文对近年来CDK/cyclin抑制剂的种类及目前其在临床应用中出现的问题进行概述。