妊娠期糖尿病糖化血红蛋白水平与产科并发症的关系

摘要

目的：探讨妊娠期糖尿病糖化血红蛋白水平与产科并发症的关系情况。方法分析我院2014年1月1日～2015年12月31日收治的100例妊娠期糖尿病患者临床资料，依据糖化血红蛋白水平变化情况进行分组，＞6.5%糖化血红蛋白组50例和≤6.5%糖化血红蛋白组50例，选取50例正常产妇作为对照组。结果≤6.5%糖化血红蛋白组FPG、1hPG、HbA1c、HOMA-IR水平均高于对照组，＞6.5%糖化血红蛋白组FPG、1hPG、HbA1c、HOMA-IR水平均高于≤6.5%糖化血红蛋白组，妊娠期糖尿病患者早产、羊水过多、巨大儿、胎膜早破、子痫前期、胎儿宫内窘迫发生率均高于对照组，＞6.5%糖化血红蛋白组患者早产、羊水过多、巨大儿、胎膜早破、子痫前期、胎儿宫内窘迫发生率均高于对照组，差异有统计学意义（P＜0.05）。结论妊娠期糖尿病糖化血红蛋白水平＞6.5%可能增加产科并发症风险性，应加强糖化血红蛋白监测。%Objective To explore the relationship between gestational diabetes mellitus glycosylated hemoglobin level and obstetric complication. Methods Clinical data of 100 cases of gestational diabetes mellitus were analyzed, which were cured in our hospital from January 1,2014 to December 31,2015.According to the change of glycosylated hemoglobin level,they were divided into > 6.5% glycosylated hemoglobin group with 50 cases and ≤ 6.5%glycosylated hemoglobin group with 50 cases. 50 cases of normal pregnant women were selected as control group. Results FPG,1hPG,HbA1c,HOMA-IR levels of ≤6.5% glycosylated hemoglobin group were all higher than those of control group,FPG,1hPG, HbA1c,HOMA-IR levels of>6.5% glycosylated hemoglobin group were all higher than those of ≤ 6.5% glycosylated hemoglobin group. Premature birth,excessive amniotic fluid,fetal distress, premature rupture of membranes,preeclampsia, fetal distress incidence rates of patients with gestational diabetes mellitus were all higher than those of control group.Premature birth,excessive amniotic fluid,fetal distress,premature rupture of membranes,preeclampsia,fetal distress incidence rates of>6.5%glycosylated hemoglobin group were all higher than those of control group,(P<0.05).All the differences were statistically significant. Conclusion Gestational diabetes mellitus glycosylated hemoglobin level > 6.5% may increase the risk of obstetric complications.It is necessary to strengthen the monitoring of glycosylated hemoglobin.