不同负荷的非器质性室性期前收缩与心率变异性的相关性分析

摘要

目的：探讨不同负荷的非器质性室性期前收缩患者对心率变异性的影响及对临床的指导意义。方法选取115例非器质性心脏疾病的室性期前收缩患者，将这些患者根据不同负荷分为三组，即A组低负荷（＜10%），B组中负荷（10%~20%），C组高负荷（＞20%）。对比3组间SDNN，SDANN，rMMSD， PNN50%等指标，并分析其相关性。结果高负荷室性期前收缩患者的时域指标SDANN明显低于低负荷及中负荷组的患者；3组之间HRV时域指标比较，SDNN，rMMSD，PNN50%差异无统计学意义（P＞0.05），而SDANN差异有统计学意义（P＜0.05）。同时，SDANN与室性期前收缩负荷存在负相关（r=-0.361， P=0.000）。结论随着非器质性室性期前收缩负荷的增加，SDANN数值显著降低，主要与自主神经受损有关。高负荷室性期前收缩患者交感神经增强更明显，如不及时治疗，发生恶性心律失常的风险将会增加。%Objective To explore the influence of non-organic ventricular premature contractions of different loads to heart rate variability of patients and its clinical guiding significance. Methods 115 cases of patients with non-organic heart disease ventricular premature contraction were selected and divided into three groups according to different loads, that were group A low load ( < 10%), group B medium load (10%-20%), group C high load ( >20%). SDNN, SDANN, Rmmsd, PNN50%and other indicators of the three groups were compared, and the correlations were analyzed. Results Time domain index SDANN of patients with high load ventricular premature contraction was significantly lower than that of patents with low load and medium load. Comparison of HRV time domain indexes between 3 groups showed that SDNN,, rMMSD, PNN50% had no significant difference (P > 0.05), while SDANN difference was significant (P < 0.05). At the same time, there was a negative correlation between the SDANN and the ventricular premature contraction (r=-0.361, P=0.000). Conclusion The SDANN value decreases significantly with the increase of non-organic ventricular premature contraction load, which is mainly related to the impairment of autonomic nervous system. Sympathetic enhancement is more obvious in patients with high load ventricular premature contraction, and the risk of malignant arrhythmia will increase if not treated in time.