Objective To study the clinical effect of mycophenolate mofetil and cyclophosphamide in the treatment of Ⅳ combined Ⅴ type lupus nephritis. Methods 88 patients with Ⅳ and Ⅴ type lupus nephritis, who were selected from January 2010 to January 2015, were randomly divided into two groups to comparative study. To apply conventional hormone therapy on patients of the two groups, thereinto, 44 patients in test group were treated with mycophenolate mofetil, while 44 patients in control group were treated with cyclophosphamide, to compare the clinical effect between the two groups. Results The total remission rate of clinical effect after treatment in test group(88.64%) was obviously higher than which in control group(68.18%), and the total incidence of adverse reactions in test group(27.27%) was obviously lower than which in control group(56.82%), the differences were statically significant (P<0.05). Conclusion The treatment of mycophenolate mofetil based on conventional hormone therapy in patients with Ⅳ combined with Ⅴ type lupus nephritis could effectively improve the clinical effect, reduce the incidence of adverse reactions, is worthy of further clinical popularization and application.%目的：探讨霉酚酸酯与环磷酰胺治疗Ⅳ型伴Ⅴ型狼疮性肾炎的临床疗效。方法2010年1月～2015年1月期间，选取88例Ⅳ型伴Ⅴ型狼疮性肾炎患者随机分为两组进行对比研究，两组患者均常规采用激素治疗，其中试验组44例给药霉酚酸酯治疗，而对照组44例给药环磷酰胺治疗，比较两组临床疗效。结果治疗后，试验组临床疗效总缓解率（88.64%）明显高于对照组（68.18%），且不良反应总发生率（27.27%）明显低于对照组（56.82%），差异有统计学意义（P＜0.05）。结论在Ⅳ型伴Ⅴ型狼疮性肾炎患者常规激素治疗的基础上，加用霉酚酸酯治疗，可有效提高其临床疗效，降低不良反应发生率，值得进一步推广应用。
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