目的:探讨血清超敏C反应蛋白(Hs-CRP)及纤维蛋白原(FIB)在糖尿病足感染患者(DFI)中的变化及临床意义.方法:分别测定42例糖尿病足患者和50例健康对照组人员空腹血糖(FPG)、Hs-CRP和FIB.结果:糖尿病足感染患者FPG为(12.32±5.69)mmol/L,显著高于对照组的(4.65±1.51)mmol/L(P<0.01);Hs-CRP为(5.24±4.64)mg/L,显著高于对照组的(1.45±1.96)mg/L(P<0.01);FIB 为(4.24±1.01)g/L,显著高于对照组的(2.90±0.80)g/L(P<0.01).结论:糖尿病足感染患者Hs-CRP和FIB的升高与糖尿病足密切相关.Hs-CRP和FIB可作为糖尿病足感染患者诊断及其转归的敏感指标,对于临床症状非典型患者更有临床意义.%Objective: To investigate the change of high sensitive C-reactive protein (Hs-CRP) and Fibrinogen (FIB) in the patients with diabetic foot infection and its clinical significance. Methods: The FPG, Hs-CRP and FIB levels of patients with diabetic foot infection and healthy people were detected respectively. Results: FPG, Hs-CRP and FIB in diabetic foot group [(12.32±5.69) mmol/L, (5.24±4.64) mg/L, (4.24±1.01) g/L] were higher than that of healthy people [(4.65 ±1.51) mmol/L, (1.45±1.96) mg/L, (2.90±0.80) g/L] (P<0.01). Conclusion: The increase of Hs-CRP and FIB in diabetic foot group may be closely related to the development of diabetic foot infection. Hs-CRP and FIB can be as the sensitive index to diagnose DFI and its outcome. It is more significant in the patients with atypical clinical symptom.
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