Objective: To explore clinical values of hypoxia inducible factor-la (HIF-la), E-selectin and sialvl lewis-X (sLeX)'s dynamic expression on evaluating hepatocellular carcinoma (HCC). Methods: Randomly selecting 45 cases of HCC specimens and normal liver tissue respectively, testing the expression of HIF-la, E-selectin and sLeX, and analyzing the correlation with above indicators. Results: The positive expression of HIF-la in HCC and normal liver tissues were 68.89％ and 8.89％ respectively, and positive expression of HIF-la, E-selectin and sLeX had positive correlation with TNM staging (rH=0.32, rE=0.35, rs=0.36), yet had negative correlation with HCC's differentiation (rH=-0.46, rE=-0.34, rs=-0.31), also had negative correlation with HCC's prognosis (rH=-0.53, rE=-0.43, rs=-0.36). Conclusion: HIF-la, E-selectin and sLeX has important relationships with HCC's occurrence, development, metastasis and prognosis, so comprehensive testing above indicators has high value to HCC's clinical evaluation.%目的:探讨缺氧诱导因子-1α(HIF-1α)、E-选择素及配体唾液酸化的路易斯寡糖-X(sLeX)的表达对肝癌的临床评价价值.方法:随机选择肝癌组织标本与正常肝组织标本各45例,采用SP法分别检测组织中HIF-1α、E-选择素及配体sLeX的表达情况,分析其与肝癌相应临床指标的相关性.结果:肝癌组织及正常肝组织HIF-1α的阳性表达率分别为68.89%和8.89%,HIF-1α、E-选择素、sLeX的阳性表达,与肝癌TNM分期呈正相关(rH=0.32,rE=0.35,rs=0.36),而与肝癌的分化程度呈负相关(rH=-0.46,rE=-0.34,rs=-0.31),与肝癌预后呈负相关(rH=-0.53,rE=-0.43,rs=-0.36).结论:HIF-1α、E-选择素、sLeX与肝癌的发生、发展、转移与预后有重要的关系,综合检测对肝癌患者的临床评价具有较高的价值.
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