Objective To observe the clinical effect of comprehensive treatment on anal fistula complicated with Crohn disease. Methods From March 2008 to March 2013 108 patients with Crohn disease complicated with anal fistula ad-mitted and treated in Dongyang People's Hospital were selected and given comprehensive treatment. Anal incontinence, healing time of fistula, remission and biological indicators were observed and a two year long follow-up was given to observe the incidence of sequelae of operation. Results After the treatment, anal incontinence score was (3.16±0.58) scores, significantly lower than before the treatment (13.67±3.97) scores, the difference was statistically significant (P<0.05). The scores of CDEIS, CDAI and subjective symptom [(2.03±0.54), (139.86±34.29), (1.07±0.53) scores], signifi-cantly better than those before treatment [(7.89±2.34), (287.04±95.45), (2.36±0.75) scores], the differences were statisti-cally significant (P<0.05). Biological indexes were significantly befter than those before treatment, the differences were statistically significant (P<0.05). The healing time of fistula of these patients was (19.07±8.72) d and there were 7 cas-es (6.48%) with seguelae. Conclusion Comprehensive treatment, in the treatment of anal fistula complicated with Crohn disease is effective in the recovery of anal function and it lessens the local symptoms, which is of the value to be put into clinical application.%目的：观察克罗恩病合并肛瘘综合治疗的临床疗效。方法选取东阳人民医院2008年3月~2013年3月收治的克罗恩病合并肛瘘患者共108例，予综合治疗，观察患者肛门失禁情况、瘘管的愈合时间、症状缓解情况及生物学指标，行2年随访观察手术后遗症发病情况。结果治疗后肛门失禁评分[(3.16±0.58)分]低于治疗前[(13.67±3.97)分]，差异有统计学意义(P<0.05)；克罗恩病内镜严重程度指数[(2.03±0.54)分]、克罗恩病简化活动指数[(139.86±34.29)分]、主观症状评分[(1.07±0.53)分]均优于治疗前[(7.89±2.34)、(287.04±95.45)、(2.36±0.75)分]，差异有统计学意义(P<0.05)；生物学相关指标均优于治疗前，差异有统计学意义(P<0.05)；患者瘘管愈合时间为(19.07±8.72)d；出现后遗症7例(6.48%)。结论克罗恩病合并肛瘘采用综合治疗能够实现患者肛门功能的恢复与局部症状的减轻，效果理想，有临床应用价值。
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