老年肺癌患者GP方案围治疗期恶心、呕吐状况评估及对Morse跌倒评分指标的影响

摘要

目的：观察老年肺癌患者GP方案围治疗期恶心、呕吐现况及对Morse 跌倒评分指标影响。方法选择2013年1~12月在辽宁省肿瘤医院住院接受GP方案化疗的老年肺癌患者95例,患者在开始化疗前、第2周期开始前及化疗结束后分别接受恶心、呕吐等级指标、恶心问卷(NP问卷)和Morse跌倒评估量表评估,并进行自身对照比较。结果接受GP方案化疗老年肺癌患者各周期无恶心、呕吐者明显少于化疗前,同时轻、中、重度恶心、呕吐者均明显多于开始化疗前,差异有高度统计学意义(P<0.01)。接受GP方案化疗老年肺癌患者第2周期开始前及化疗结束后NP各项因子分及NP总分均明显高于开始化疗前,差异有统计学意义(P<0.05)。接受GP方案化疗老年肺癌患者第2周期开始前及化疗结束后Morse量表中多数条目分及Morse总分均明显高于开始化疗前,差异有统计学意义(P<0.05)。95例接受GP方案化疗肺癌患者中,围治疗期发生化疗所致恶心呕吐(CINV)者81例(85.26%),未发生CINV者14例(14.74%),CINV者Morse量表中各个条目分及Morse总分均明显高于无CINV患者,差异有统计学意义(P<0.05)。结论接受GP方案化疗老年肺癌患者围治疗期间发生恶心、呕吐频度高、程度重,并明确影响到了Morse跌倒评分指标。%Objective To evaluate the effect of GP chemotherapy on nausea, vomit and Morse fall scales of elder pa-tients with lung cancer. Methods From January to November 2013, in Liaoning Cancer Hospital & Institute, 95 pa-tients with lung cancer treated with combined GP regime chemotherapy were selected, The indicator of nausea and vomiting, nausea questionnaire (NP) and Morse fall scales were evaluated compared with themselves before chemothera-py, the second chemotherapy cycle and after all the chemotherapy cycles. Results Non-nausea and non-vomit in the patients with elderly lung cancer at any time after chemotherapy were significantly less than that before chemotherapy, and patients with mild and severe nausea and vomit were more than those before chemotherapy, the differences were statistically significant (P<0.01). NP questionnaire every factor and total scores before the second chemotherapy and af-ter all the chemotherapy were significantly higher than those before the first chemotherapy, the differences were statistical-ly significant (P<0.05). Most item scales and total scale in the Morse fall scale testing were significantly higher than those before chemotherapy, the differences were statistically significant (P<0.05). Among 95 elderly patients with lung can-cer, 81 patients (85.26%) occurred CINV and 14 patients (14.74%) were without CINV. The every item scale and Morse total scale of CINV patients were significantly higher than those of non-CINV patinets, the differences were statistically significant (P< 0.05). Conclusion Higher, worse nausea and vomiting during chemotherapy are associated with GP regime chemotherapy in elderly patients with lung cancer, and greatly affect Morse fall scales.