D-二聚体预测社区获得性肺炎死亡风险的系统评价及Meta分析

摘要

目的：评价血D-二聚体预测社区获得性肺炎(CAP)患者死亡风险的作用。方法检索数据库Pubmed、Ovid、Embase及Cochrane图书馆2014年10月20日之前发表的文献,收集D-二聚体与CAP患者住院病死率或30 d病死率有关的文献,采用统计软件RevMan 5.1和STATA 12.0进行Meta分析。结果选入研究7个,共纳入1427例患者。结果显示CAP患者死亡风险随着D-二聚体水平的升高而上升(OR=4.23,95%CI：2.26~6.20,P<0.01)。结论 D-二聚体可预测CAP患者的死亡风险。%Objective To assess the role of D-dimer in predicting mortality risk in patients with community-acquired pneumonia (CAP). Methods papers published before October 20, 2014 were searched in PubMed, Embase, Ovid and the Cochrane Library, that reported the relationship between D-dimer and in-hospital mortality or 30-day mortality in CAP patients. RevMan 5.1 and STATA 12.0 were used to perform the Meta-analysis. Results 7 studies were included, involving 1427 patients. The mortality risk was increased in patients with higher D-dimer level (OR=4.23, 95%CI:2.26-6.20, P<0.01). Conclusion D-dimer can predict the mortality risk in CAP patients.