自拟益气活血方治疗老年H型高血压气虚血瘀证的临床研究

摘要

目的 观察自拟益气活血方对老年H型高血压病气虚血瘀证患者血压及同型半胱氨酸(Hcy)的水平的影响.方法 选取2015年1月～2016年12月安徽省立医院60例老年H型高血压病气虚血瘀证患者,采用随机单盲对照试验设计,根据随机数字表法分为对照组(30例)和治疗组(30例).对照组予以降压西药常规治疗,治疗组在对照组基础上服用自拟益气活血方治疗,治疗4周后观察两组降压疗效、中医症候疗效、中医症候积分及诊室血压(CBP)、动态血压(ABPM)、Hcy水平.结果 治疗组降压有效率为83.3％,对照组为60.0％,差异有统计学意义(P＜0.05);治疗组中医症候有效率为86.6％,对照组为50.0％,差异有统计学意义(P＜0.05).与治疗前相比,除Hcy和中医症候积分外,对照组治疗后CBP、ABPM明显降低(P＜0.05),治疗组治疗后Hcy、CBP、ABPM和中医症候积分均明显降低(P＜0.05),同时治疗组较对照组治疗后明显降低(P＜0.05).结论 自拟益气活血方治疗老年H型高血压病气虚血瘀证患者降压效果明显,临床症状缓解明显.%Objective To observe the effect of YiQi Huoxue Decoction on the blood pressure and homocysteine (Hcy) in senile patients with H type hypertension with syndrome of Qi deficiency and blood stasis.Methods This was arandomized single-blind control test.From January 2015 to December 2016,60 senile patients with H type hypertension with syndrome of Qi deficiency and blood stasis in Anhui Provincial Hospital were selected and divided into control group (30 cases) and treatment group (30 cases),according to random number table.The control group was treated with conventional antihypertensive therapy,and the treatment group was treated with YiQi Huoxue Decotion on the basis of the control group.The antihypertensive effect,traditional Chinese medicine symptoms efficacy,traditional Chinese medicine symptom score and consulting room blood pressure (CBP),ambulatory blood pressure (ABPM),level of Hcy in the two groups four weeks after treatment were compared.Results The antihypertensive effect rate was 83.3％ in the treatment group and 60.0％ in the control group,with statistically significant difference (P ＜ 0.05).The effective rate of Chinese medicine symptoms was 86.6％ in the treatment group and 50.0％ in the control group,with statistically significant difference (P ＜ 0.05).Compared with before treatment,the CBP,ABPM significantly decreased in the control group after treatment (P ＜ 0.05),excepted for Hcy and traditional Chinese medicine symptom score;and Hcy,CBP,ABPM and traditional Chinese medicine symptom score were significantly lower in the treatment group after treatment (P ＜0.05);at the same time,the difference between two groups have statistical significance after treatment (P ＜ 0.05).Conclusion YiQi Huoxue Decoction in the treatment of senile patients with H type hypertension with syndrome of Qi deficiency and blood stasis has obvious antihypertensive effect and clinical symptoms can be relieved.