介入有氧运动及肺康复训练联合吸入舒利迭与噻托溴铵对中重度COPD患者肺功能、运动耐力及生活质量的影响

摘要

目的 探讨介入有氧运动及肺康复训练联合吸入舒利迭与噻托溴铵对中重度慢性阻塞性肺疾病(COPD)患者肺功能、运动耐力及生活质量的影响.方法 选取西安医学院附属医院2013年7月～2015年7月收治的147例中重度COPD患者,将其随机分为试验组1、试验组2和对照组,各49例.对照组采用药物治疗,试验组1采用有氧运动进行干预,试验组2采用有氧运动联合肺康复训练及药物干预.干预8周后,观察三组患者的肺功能、运动耐力及生活质量的变化.结果 试验组2的肺活量、用力肺活量、最大通气量均明显优于对照组和试验组1,差异有统计学意义(JP＜0.05);试验组2的分泌型免疫球蛋白A、去甲肾上腺素含量均显著低于对照组和试验组1,差异均有统计学意义(P＜0.05).试验组2的6 min步行试验明显高于对照组和试验组1,生活质量评分明显低于对照组和试验组1,差异均有统计学意义(P＜0.05).结论 对中重度COPD患者进行综合有氧运动及肺康复训练联合吸入舒利迭与噻托溴铵干预可以提高患者的肺功能、运动耐力和生活质量,值得推广应用.%Objective To explore the effects of the intervention of aerobic exercise and pulmonary rehabilitation training combined with inhalation of Seretide and Tiotropium Bromide for the pulmonary function,exercise tolerance and quality of life in patients with moderate-severe chronic obstructive pulmonary disease (COPD).Methods One hundred and forty-seven patients with moderate-severe COPD admitted to the Affiliated Hospital of Xi'an Medical University from July 2013 to July 2015 were selected and randomly divided into experimental group 1,experimental group 2 and control group,with 49 cases in each group.The control group was given drug therapy,the experimental group 1 was given aerobic exercise intervention,the experimental group 2 was given the aerobic exercise combined with pulmonary rehabilitation training and drug intervention.After intervention for 8 weeks,the changes of pulmonary function,exercise tolerance and quality of life among the three groups were observed.Results The vital capacity,forced vital capacity,maximal voluntary ventilation in the experimental group 2 were better than those of control group and experimental group 1,the differences were statistically significant (P ＜ 0.05);the contents of secretary immunoglobulin A,nora-drenaline in the experimental group 2 were all lower than those of control group and experimental group 1,the differences were statistically significant (P ＜ 0.05);the 6 min walking test in the experimental group 2 was higher than that of control group and experimental group 1,the score of quality of life was higher than that of control group and experimental group,the differences were statistically significant (P ＜ 0.05).Conclusion Intervention of comprehensive aerobic exercise and pulmonary rehabilitation training combined with inhalation of Seretide and Tiotropium Bromide for patients with moderate-severe COPD can improve the pulmonary function,exercise tolerance and quality of life,which is worthy of promotion and application.