宫颈环形电极切除术与微波治疗慢性宫颈炎的疗效比较

摘要

Objective:To compare the effects of Leep knife and microwave on patients with chronic cervicitis. Methods: One hundred and thirty-four patients with chronic cervicitis were randomly divided into two groups, the observation group(n=68 cases) received Leep knife and the control group(n=66 cases) were treated through microwave. Tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6) were detected before and after treatment. Results: The cure rate and total efficicities of the mild chronic cervicitis in the two groups were 100.0%, 94.9% and 100.0%, respectively; that of moderate to severe chronic cervicitis in the two groups were 88.5%, 63.0% and 100.0%, 85.2%(x2=14.45,x2=12.43;P<0.05). The in-traoperative blood loss and the time of vaginal fluid were(5.1±3.3)ml and (7.9±3.4)d, (11.5±3.2)ml and(15.1±3.5)d in the two groups(t=11.9,t=12.6;P<0.05).The incidence of postoperative wound infection, cervical ectropion, cervical scar, exuvial hemorrhage and recurrence were 0.0%, 2.9%, 2.9%, 2.9%, 2.9% in the observation group were lower than those( 6.1%, 6.1%, 13.6%, 15.2%, 10.6%) in the control group(x2=11.7, x2=10.8,x2=15.2,x2=15.7,x2=12.3;P<0.05). The levels of TNF-α and IL-6 decreased after treatment in both groups. There was significant difference between the two groups after treatment(P<0.01). Conclusion: Leep knife could make more significant improvement in the inflammatory status of patients with moderate to severe chronic cervicitis.%目的：比较宫颈环形电极切除术(LEEP)与微波治疗慢性宫颈炎的临床疗效。方法：选取134例慢性宫颈炎患者，随机将其分为观察组和对照组，观察组68例，接受LEEP治疗；对照组66例，接受微波治疗；测定治疗前后患者血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)。结果：两组患者轻度慢性宫颈炎的治愈率及总有效率均为100.0%，均无差异；两组患者中度、重度慢性宫颈炎的治愈率及总有效率相比，差异均有统计学意义(x2=14.45，x2=12.43；P＜0.05)。观察组术中出血量、术后阴道排液时间分别为(5.1±3.3)ml、(7.9±3.4)d，均显著低于对照组的(11.5±3.2)ml、(15.1±3.5)d，其差异均有统计学意义(t=11.9，t=12.6；P＜0.05)；观察组术后创面感染发生率、宫颈外翻、宫颈瘢痕率、脱痂出血率以及复发等发生率为0.0%、2.9%、2.9%、2.9%及2.9%，明显低于对照组的6.1%、6.1%、13.6%、15.2%及10.6%，其差异均有统计学意义(x2=11.7，x2=10.8，x2=15.2，x2=15.7，x2=12.3；P＜0.05)。两组治疗后患者血清TNF-α和IL-6均明显降低，观察组治疗后患者血清TNF-α和IL-6明显低于对照组，差异均有统计学意义(P＜0.01)。结论：LEEP用于中度、重度糜烂的慢性宫颈炎，其疗效确切，不良反应小，具有较好的临床应用价值。