液相色谱法测定一次性使用聚烯烃输液器中抗氧剂在紫杉醇注射液中的溶出

摘要

本文建立了液相色谱法测定输液器中四-[β-（3，5-二叔丁基-4-羟基苯基）丙酸]季戊四醇酯（抗氧剂1010）和亚磷酸三（2，4-二叔丁基苯基）酯（抗氧剂168）在紫杉醇注射液中的溶出情况，结果表明：两种抗氧剂的检测限依次为0.38µ g/m l和1.58µ g/m l，在3个浓度水平上对方法做回收试验，测得回收率为109.9%和81.0%。该方法简便、快速、准确，适用于紫杉醇注射液中抗氧剂1010和抗氧剂168的检测。%To develop the high performance liquid chromatography (HPLC) method for investigation of the dissolution of Irgafos 168 and Irganox 1010 in paclitaxel injection. Detection limits found for Irganox 1010 and Irgafos 168 were 0.38µg/ml and 1.58µg/ml. Recovery tested at 3 concentration levels were 109.9% and 81.0%.The method was simple, efifcient and accurate and suitable for analysis of Irgafos 168 and Irganox 1010 in paclitaxel injection.