EphB4-EphrinB2双向信号传导在骨重建中的作用

摘要

Bidirectional Eph-Ephrin signaling as a focal point of research in cell-cell communications is critical for gen-eration of nerves and vesssels as well as invation and metastasis of tumor cells. The roles for Ephrin-Eph bidirectional signaling in bone remodeling were important. EphrinB2 is expressed on osteoblasts and EphB4 is expressed on osteoclasts. Forward sig-naling through the EphB4 receptor into mesenchymal precursors promotes osteoblast differentiation ,while reverse signaling through the EphrinB2 ligand into osteoclast suppresses differentiation. Signaling between the ligand EphrinB2 and the recep-tors EphB4 explains bidirectional signaling between osteoblasts and osteoclasts ,bone absorption and remodeling ,which may lay a theoretical foundation for identifying drug targeting and preventing and treating bone loss.%Eph-Ephrin双向信号传导机制是近年来细胞间的通讯机制的研究热点，在神经系统、血管内皮系统及肿瘤形成和转移方面发挥着重要的作用。研究发现该信号传导系统在骨重建中发挥重要作用。破骨细胞上存在EphrinB2配体，成骨细胞前体上存在EphB4受体，以细胞直接接触的方式，通过胞内酪氨酸激酶信号系统，在成骨细胞和破骨细胞内分别产生正向和反向信号，促进成骨细胞前体分化成熟，同时抑制破骨细胞功能，并促进其凋亡。