骨桥蛋白表达与胃癌风险相关性的Meta分析

摘要

Objective To systematically review the correlations between osteopontin (OPN) protein expression and different clinical pathological features of gastric cancer (GC).Methods The published studies were searched in the PubMed,Cochrane Library,CBM,etc.Relevant journals were also handsearched to identify all the relevant case-control studies.The quality of the included studies was assessed.The Cochrane Collaboration's software RevMan 5.30 was used to test the heterogeneity,overall effect and publication bias of the combined studies.Results A total of 17 studies including 1,965 patients were recruited.Compared with the non-cancerous gastric tissue group,OPN expression level was significantly higher in the GC.There was a significantly higher OPN expression rate in the lymph node positive group than in the lymph node negative group.OPN expression rate in the patients with distant metastasis was higher than that in the patients without distant metastasis.Furthermore,OPN expression increased with the increase in the invasive depth,progress degree,differentiation degree and TNM staging.Conclusions OPN can be served as an important reference index for early diagnosis of gastric cancer and evaluation of biological characteristics of GC.%目的 系统评价胃癌(GC)组织中骨桥蛋白(OPN)表达与不同临床病理特征的关系.方法 计算机检索PubMed、Cochrane Library等数据库,并手工检索相关研究.应用RevMan 5.3软件进行Meta分析.结果 入选17个研究,共1 965例患者.OPN在GC表达率较对照组升高.有淋巴结转移、远处转移患者OPN阳性率高于无淋巴结转移、无远处转移患者.OPN表达随GC的浸润深度、进展程度、分化程度、TNM分期的升高而升高.结论 OPN可以作为GC临床诊断和评价生物学特性的重要参考指标.