Mohs显微手术治疗乳房外Paget病42例

摘要

目的:评价Mohs治疗乳房外Paget病的疗效.方法:42例乳房外Paget病患者沿皮损周围2 cm行 Mohs手术切除,确认边缘结果阴性之后行皮瓣或植皮闭合.术后31例患者使用光动力,每周1次,共4次.11例外用咪喹莫特乳膏,每日1次,共半年,随访8~36个月.结果:6例患者复发,复发率14.3%,其中4例为术后光动力治疗患者,2例为术后外用咪喹莫特乳膏.结论:EMPD进行Mohs显微描记手术结合光动力治疗或外用咪喹莫特乳膏有效.%Objective: To assess the efficacy of Mohs microgrphic surgery in the treatment of extramammary Paget''s disease (EMPD).Methods: The lesions and skin around the lesions of 2 cm were removed by Mohs micrographic surgery and the wounds were given skin graft after confirmed negativity for tumor cells.After the surgery, 31 patients were given photodynamic therapy, once a week for 4 times and 11 were given local imiquidod cream, once a day for 6 months.All the patients were followed up for 8-36 months.Results: Six patients relapsed and the recurrence rate was 14.3%.Out of the 6 patients, 4 were treated with photodynamic therapy and 2 were treated with local imiquidod cream after Mohs micrographic surgery.Conclusion: Mohs micrographic surgery combined with the photodynamic therapy or imiquimod cream is effective in the treatment of EMPD.