Objective Curative effect observation on early application in treatment to functional class III-IV heart failure with small dose of dopamine combined with furosemide. Methods 84 patients, with cardiac functional class III-IV heart failure, accept-ed by the Department of Cardiology, Changchun Second Hospital, from August 2012 to December 2014, were selected and ran-domly divided into two groups, the treatment group, 42 cases, early made intravenous continuous infusion of small dose dopamine (0.5-1.0 ug·kg-1·min-1) combined with furosemide (20-40mg/d) intravenous injection therapy, while control group, 42 cases, only made intravenous injection of furosemide (20-40mg/d). Therapeutic effects, left ventricular ejection fraction (LVEF), left ven-tricular internal diameter at end-diastole (LVIDd) and B-type natriuretic peptide (BNP) levels were compared. Results The total effective rate of treatment group was 90.48% (38/42), and the total efficiency of control group 73.81% (31/42), so the difference was statistically significant (X2=3.153, P=0.0012). LVEF, LVIDd, and BNP levels of the two groups were improved after treatment, and the treatment group's improvement was better than that of the control group, with statistical significance, P<0.05. Conclusion Early application of small dose dopamine combined with furosemide, patients with cardiac functional class III-IV heart failure, car-diac function and therapeutic effect could be improved.%目的：探究早期应用小剂量多巴胺联合呋塞米治疗心功能III-IV级心力衰竭的疗效。方法整群选自2012年8月-2014年12月长春市第二医院心内科就诊的84例心功能III-IV级心力衰竭的患者，随机分为两组，治疗组42例早期给予静脉持续泵入小剂量多巴胺（0.5-1.0ug.kg-1.min-1）联合呋塞米（20-40mg/d）静脉注射治疗，对照组42例仅静脉注射呋塞米（20-40mg/d）。比较两组治疗效果、左室射血分数（LVEF）、左室舒张末内径（LVIDd）和B型利钠肽（BNP）水平。结果治疗组总有效率90.48%（38/42），对照组总有效率73.81%（31/42），两组比较差异有统计学意义（χ2=3.153，P=0.0012）。治疗后两组LVEF、LVIDd、BNP水平均有改善，治疗组改善优于对照组，差异有统计学意义，P<0.05。结论早期应用小剂量多巴胺联合呋塞米可改善心功能III-IV级心力衰竭患者的心功能，提高治疗效果。
展开▼
