Objective To study the clinical signs and immune status of HFMD caused by different pathogens. Methods 100 cases with HFMD from June 2013 to June 2014 in our hospital were researched. They were divided into two groups by different pathogens, EV71 positive for EV71 group and CoxA16 positive for CoxA16 groups. The clinical signs (the highest body tempera-ture, blood sugar, white blood cells, limb shaking) and immune status (IgG, IgA, IgM) were compared between the two groups. Re-sults There was no significant difference in the highest temperature and the white blood cells of EV71 group and CoxA16 group (P>0.05);blood glucose was higher in EV71group;limb shaking ratio of EV71 group, 72%, was significantly higher than that of the CoxA16 group, 34%;IgG, IgM of EV71 group and CoxA16 group had no significant difference;IgA of EV71 group was higher than that of CoxA16 group, and there was a significant difference (P<0.05). Conclusion Glucose and limb shaking should be considered as a means in the differential diagnosis of EV71 infection and CoxA16 infection and offer help for the early identification of pathogen species.%目的：研究不同病原体感染手足口病患儿的临床体征及其机体免疫状况的对比。方法随机选择2013年6月—2014年6月该院接诊的100例不同病原体感染手足口病患儿进行研究。将其按病原体种类进行分组，EV71阳性的为EV71组， CoxA16阳性的为CoxA16组。比较两组患者的临床体征（最高体温、血糖、白细胞、肢体抖动）及其机体免疫状况（IgG、IgA、IgM）。结果 EV71组与CoxA16组的最高体温与白细胞相比差异无统计学意义(P＞0.05）；EV71组的血糖高于CoxA16组， EV71组与CoxA16组的肢体抖动比率分别为72%与34%，EV71组明显高于CoxA16组。 EV71组与CoxA16组的IgG、IgM相比较差异无统计学意义，EV71组的IgA高于CoxA16组，二者相比差异有统计学意义(P＜0.05）。结论患儿的血糖、肢体抖动可以作为鉴别EV71感染与CoxA16感染的鉴别诊断之一，便于手足口病病原体种类的早期鉴别。
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