静脉滴注单硝酸异山梨酯治疗冠心病心绞痛的临床疗效及安全性

摘要

Objective to probe into and analysis of intravenous drip of isosorbide mononitrate and treatment of coronary heart dis-ease angina pectoris clinical efficacy and safety. Methods select our hospital from October 2012 to October 2012 were 60 cases of patients with coronary heart disease angina pectoris, take a random number table method is divided into isosorbide mononitrate and nitroglycerin group, 30 cases in each group. Compared two groups of clinical curative effect and safety. Results the isosorbide mononitrate group total effective rate was 93.33%, nitroglycerin group total effective rate was 76.67%, compared two groups of effi-cient has significant difference (chi-square=5.67, P<0.05). Isosorbide mononitrate group total incidence of adverse reactions was 10.00%, the total incidence of adverse reactions was 26.67% nitroglycerin group, compared two groups of incidence of adverse re-actions has significant difference (chi-square = 5.23, P < 0.05). Conclusion the intravenous drip of isosorbide mononitrate and treatment of coronary heart disease angina pectoris clinical curative effect is distinct, less adverse reaction, high security, is worth promoting.%目的：探究与分析静脉滴注单硝酸异山梨酯治疗冠心病心绞痛的临床疗效及安全性。方法选取该院自2012年10月—2014年10月收治的60例冠心病心绞痛患者，采取随机数字表法分为单硝酸异山梨酯组与硝酸甘油组，每组30例。对比两组临床疗效及安全性。结果单硝酸异山梨酯组总有效率为93.33%，硝酸甘油组总有效率为76.67%，两组有效率相比差异有统计学意义（χ2=5.67，P＜0.05）。单硝酸异山梨酯组总不良反应发生率为10.00%，硝酸甘油组总不良反应发生率为26.67%，两组不良反应发生率相比差异有统计学意义（χ2=5.23，P＜0.05）。结论采用静脉滴注单硝酸异山梨酯治疗冠心病心绞痛的临床疗效显著，不良反应少，安全性较高，值得推广。