合并心房纤颤的急性缺血性卒中患者静脉溶栓疗效及安全性分析

摘要

Objective To observe the efficacy and safety of intravenous thrombolysis in acute ischemic stroke patients with atrial fibrillation. Methods The patients with acute cerebral infarction within 4.5 h of onset were divided into atrial ifbrillation group and atrial ifbrillation group, and intravenous thrombolytic therapy was performed.Observation of 24 h and 14 d NIHSS score after thrombolysis; 90 d patients with good prognosis, the incidence of intracranial hemorrhage during hospitalization, the incidence of symptomatic intracranial hemorrhage. Results After 90 d patients with a good prognosis without atrial ifbrillation were higher than those in the atrial fibrillation group. The incidence of intracranial hemorrhage in patients with atrial fibrillation was higher than that in the patients without atrial ifbrillation. And the difference was statistically signiifcant. The incidence and mortality rate of symptomatic intracranial hemorrhage, there was no significant difference between two groups.Conclusion Intravenous thrombolysis in patients with acute ischemic stroke and atrial fibrillation has signiifcant effects.%目的：观察合并心房纤颤的急性缺血性卒中患者静脉溶栓疗效及安全性。方法选择起病4.5 h内的超急性期脑梗死患者，分为心房纤颤组和无心房纤颤组，进行静脉溶栓治疗，观察溶栓后24 h及14 d NIHSS评分；90 d时患者预后良好发生率；住院期间颅内出血、症状性颅内出血的发生率。结果90 d时获得良好预后无心房纤颤组高于心房纤颤组，心房纤颤组颅内出血的发生率高于无心房纤颤组，且差异具有统计学意义。症状性颅内出血的发生率及死亡率，两组间差异无统计学意义。结论采用静脉溶栓对急性缺血性卒中合并心房纤颤患者进行治疗的效果显著。