低氧诱导因子-1α基因在藏鸡低氧适应机制中的研究进展

摘要

Hypoxia inducible factor-la (HIF-1α) is a transcriptional factor that plays an essential role both in organisms' adaptation to hypoxia and maintenance of oxygen homeostasis. Under normoxia, synthesized HIF-la protein protein will be degraded immediately; under hypoxia. Stabilized HIF-la protein will dimerize with HIF-1β　 to form HIF-1 which could regulate oxygen homeostasis. Tibetan chicken have been living in high altitude and low-O2 tension environment for many centuries, and has special molecular pathways for adaptation to hypoxia. This review will summary the genetic structure of HIP-1α gene and its role in hypoxia adaptation of Tibetan chicken .%作为调控氧稳态的主要转录因子,低氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)对维持机体氧平衡和适应低氧环境具有关键作用.常氧环境条件下,HIF-1α蛋白持续合成并被不断降解；低氧环境条件下,HIF-1α蛋白降解受阻并与HIF-1β转录因子二聚化形成HIF-1作用于其靶基因发挥低氧调节作用,维持机体在低氧条件下的生存.世代生活在高原低氧环境中的藏鸡,形成了完整的适应低氧环境遗传机制.作者将系统介绍HIF-1α基因结构、编码产物特征及其低氧适应作用机理,并探讨藏鸡HIF-1α基因参与其低氧适应的遗传机制的研究进展.