蛋白质的糖基化作用及其在生物制药中的应用

摘要

糖基化是生物体一种最为常见且最主要的蛋白质翻译后修饰方式,对蛋白质性状及其功能的影响具有重要的生物学意义.近年来,随着糖生物学与糖基化工程的发展,已有越来越多的药物应用于临床.文章概括了蛋白质糖基化修饰的种类及糖基化修饰对蛋白质特性的影响；在此基础上,总结了近年来蛋白质糖基化工程在生物制药中的发展与应用.蛋白质糖基化工程作为一种新型的改良蛋白质性质的手段,必然会在蛋白质的改造中发挥越来越重要的作用.%Glycosylation is the most common and most important protein post-translational modification of proteins in organism. It affects the characters and function of proteins significantly. In recent years, more and more drugs have been applied in clinic along with the development of glycobiology and glycosylation engineering. In the paper, we summarized the species of glycosylation modification and their effect on the protein properties. On the basis, the development and application of protein glycosylation engineering in the biological pharmacy were described. Protein glycosylation engineering will inevitably play an increasingly important role in the protein transformation as a new type of protein-modification means.