氨基酸对哺乳动物脂质代谢的调控及其作用机理

摘要

Lipid metabolism not only affects human health but also is vital to livestock and poultry production.Therefore,it is necessary to study the nutrition regulation strategy of lipid metabolism.This paper mainly introduces the four amino acids which are important for the regulation of lipid metabolism,including methionine (Met),leucine (Leu),arginine (Arg) and glutamate (Glu),and summarizes the regulation effects and mechanism on lipid metabolism of the four amino acids at the physiological level,cellular level and molecular level.This paper introduces these four amino acids in the role of nutritional research,physiological effects in animal experiments,the mechanism of regulation effect on lipid metabolism and the combination effect.Meanwhile,the regulation and mechanism of amino acid on lipid metabolism in adipose,liver and muscle tissue were emphatically discussed.This paper reviews the progress of four amino acids in basic research and livestock production application,and further analyze the potential directions in the future research on the deep mechanism of lipid metabolism to clarify the regulation effects and potential mechanism of the amino acids on mammals' lipid metabolism,which was aimed to provide a reference for the accuracy using of amino acids.%脂质代谢不仅影响人类健康,对畜禽生产也至关重要,研究脂质代谢的营养调控策略有重要意义.作者主要介绍了蛋氨酸(Met)、亮氨酸(Leu)、精氨酸(Arg)和谷氨酸(Glu)这4种对脂质代谢调控作用显著的氮基酸.从生理水平、细胞水平和分子水平上总结了4种氨基酸对哺乳动物脂质代谢的调控及其作用机理,并从4种氨基酸在营养学研究中的作用、在动物试验中的生理效应、对脂质代谢调控的作用机理及各种氨基酸的组合效应等方面进行综述,重点综述了氨基酸对脂肪、肝脏和肌肉组织脂质代谢的调控及其作用机理.同时回顾了4种氨基酸在基础研究与畜牧生产应用上取得的进展,进一步分析了未来研究氨基酸对脂质代谢调控深层机理的可能方向,以期为氨基酸的精准利用提供参考.