2-芳氧基-噻吩并2,3-d嘧啶-4(3H)-酮衍生物的合成

摘要

采用串联氮杂Wittig反应,合成了5种未见文献报道的2-芳氧基-噻吩并[2,3-d]嘧啶-4(3H)-酮衍生物.首先由膦亚胺与芳基异氰酸酯反应得到碳二亚胺,再与取代酚在碳酸钾的催化下反应得到目标化合物,收率为62％～85％,并采用元素分析、IR、MS、1 HNMR等手段对目标化合物的结构进行了确证.%kinds of 2-aryloxy-thieno[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized by aza- Wittig reaction. Firstly carbodiimides were synthesized by iminophosphorane and aromatic isocyanates, then, the object compounds were synthesized by carbodiimides and substituted phenol in the presence of catalyst solid K2CO3 with yield of 62% ? 85%. And their structures were characterized by elemental analysis, IR, MS, 1HNMR.