One Step Fabrication and Application of Antibacterial Electrospun Zein/Cinnamon Oil Membrane Wound Dressing via In situ Electrospinning Process

摘要

Antibacterial wound dressing can benefit the wound healing by preventing bacterial infection,especially for the electrospun ones due to their porous structures and easily loading antibacterial drugs.However,it is challenging to apply the antibacterial electrospun wound dressing to covering the wound conveniently and safely.Here,we presented one step fabrication and application of antibacterial electrospun zein/cinnamon oil wound dressing via a handheld electrospinning setup.The prepared zein/cinnamon oil wound dressing showed gas permeability of(76.1-5.45)mm/s,hydrophilicity with zero body fluid contact angle,swelling stability after 24 h as well as antibacterial zones over 5 cm against both E.coli and S.aureus bacteria.Moreover,in situ electrospinning process can deposit the electrospun zein/cinnamon oil fibers directly onto the wound,meantime forming a wound dressing.The mice cut-wound model experiment demonstrated that the one step in situ fabrication and application of zein/cinnamon oil wound dressing could nearly heal the wound within 11 d.