银盐法合成6-(4-卤代苯基)-3(2H)-哒嗪酮葡萄糖苷

摘要

Four pyridazinone gluosodes 4 were synthesized by Koenig'' s-Knorr reaction of 6-(4-halophenyl)-3 (2H)-pyridazinone silver salt 2 with bromoaeetylglueose 3. Treatment of 4 with dry ammonia at 0 ～ - 5 ℃ effeeted a removal of the acetyl protecting groups to yield compounds 5. When the substituent on the benaene ring was F-or Cl-,O-glueoside was synthesized prineipaUy. However, when the substituent was Br-or I-, N-glueoside was mainly obtained. Their struetures were confirmed by 1H NMR, IR and elemental analysis.