The Pt catalysts with mass fractions of 4％ and 10％ were supported on MPC-61, a kind of ordered mesoporous carbon, by an impregnation method using two different Pt precursors, ethanolic solution and aqueous solution of H2PtCl6. These Pt/MPC-61 catalysts were characterized by XRD, N2-sorption, TEM and CO chemisorption. The Pt/MPC-61 catalysts were applied in the asymmetric hydrogenation of ethyl pyruvate after chirally modified with cinchonidine. The Cat-4Pt-E catalyst derived from the ethanolic solution of H2PtCl6 afforded higher conversions of ethyl pyruvate due to smaller Pt particle size with higher Pt dispersion. While the Cat-4Pt-W catalysts derived from the aqueous solution of H2 PtCl6 showed higher chiral induction ability.The catalyst Cat-4Pt-W-150, which was calcined at 150 ℃ under vacuum, gave higher conversion and enantioselectivity than Cat-4Pt-W did, the highest TOF reaching 8820 h - 1 in water. A 66％ e. e. value was furnished by Cat-10Pt-E catalyst in acetic acid. In particular, the Cat-4Pt-W catalyst showed superior catalytic activity to the commercial 5％ (mass fraction) Pt/C catalyst, mainly due to the ordered mesoporous structure feature of MPC-61 support. Cat-4Pt-W can also be reused for more than 10 times without distinct loss of activity or enantioselectivity. The 4％ Pt/MPC-61 catalysts can also be effectively applied in the asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutyrate, of which the hydrogenation product can be used to produce A. C. E inhibitors.Under the optimal conditions, the catalyst Cat-4Pt-W-150 gave a 61％ e. e. value of (R)-( + )-ethyl 2-hy-droxyl-4-phenylbutyrate in acetic acid.%采用氯铂酸乙醇溶液和氯铂酸水溶液为前体,通过浸渍法制备了介孔碳材料MPC-61负载Pt质量分数分别为4%和10%的Pt/MPC-61催化剂,并利用XRD,TEM,N2吸附-脱附和CO化学吸附等手段对催化剂进行了表征.考察了经过手性分子辛可尼定修饰后的Pt/MPC-61催化剂在丙酮酸乙酯不对称氢化反应中的催化性能.以氯铂酸乙醇溶液为前体制备的担载质量分数为4%的催化剂因具有较小的粒径和较高的分散度而表现出较高的活性,而以氯铂酸水溶液为前体制备的相同Pt担载质量分数的催化剂则具有较强的手性诱导能力.前体经150℃真空焙烧制得的催化剂无论是反应活性还是光学选择性均有所提高,在水溶剂中的TOF值高达8820 h-1.Pt担载质量分数为10%的催化剂在乙酸溶剂中对R-(+)-乳酸乙酯的光学选择性可以达到66%e.e..Pt担载质量分数为4%的Pt/MPC-61催化剂表现出比质量分数为5%的商品化Pt/C催化剂更高的催化活性,且可重复使用10次以上.在将Pt担载质量分数为4%的催化剂用于手性药物依那普利前体的不对称合成中时,前驱体经150℃真空焙烧制得催化剂在乙酸溶剂中的光学选择性可达61%e.e..
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