Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma

摘要

The epithelial-mesenchymal transition(EMT)is a highly complex phenotypic conversion during embryogenesis,and is important for metastasis,which contributes to tumor deterioration and poor prognoses of cancer patients.Lung carcinoma has a high tendency to develop the EMT.Circular RNAs(circ RNAs)are involved in EMT-related cell invasion and metastasis in various types of cancers.Moreover,circ RNAs have been found to be a link to EMT-related transcription factors and EMT-associated signaling pathways.This review mainly focuses on the influence of EMT-related circ RNAs on lung carcinomas.More specifically,the roles of EMT-inducingand EMT-suppressive circ RNAs in lung carcinomas are discussed.With circ RNAs potentially becoming promising biomarkers and therapeutic targets for cancer managements,they will hopefully stimulate the interest of medical workers in the early diagnosis,personalized treatment,and positive prognoses in the era of precision oncology.