Double Primary Cancers in Extragastric Sites with Gastric Cancer: Report of Six Cases and Literature Review

摘要

OBJECTIVE To explore the clinical features, pathologiccharacteristics and prognosis of double primary malignant tumorswith involvement of the stomach and an extragastric site.METHODS We reviewed the records of 496 patients whounderwent surgery for gastric cancer in our department fromJanuary 2004 to December 2006. Synchronous double primarycancer was defined as an extragastric cancer diagnosed within a6-month interval before the detection of gastric cancer; any gastriccancer metastasis to other areas of the body was excluded.RESULTS Synchronous and metachronous double primarycancers were identified in 1 and in 5 patients, respectively. Theextragastric sites of the primary tumors in patients with gastriccancer were esophagus in 1 case, right colon in 1, rectum in 1,breast in 2 and lung in 1. Following gastric surgery, 5 patientsdied (within 2 mon, 24 mon, 30 mon, 48 mon and 60 mon). Only 1patient has survived and remains disease free.CONCLUSION The prognosis of patients with gastric cancerand a second primary is relatively poor. It is necessary to performregular esophagogastroduodenoscopy (EGD) on patients whohave been diagnosed with extragastric cancer, regardless of theirsymptoms.