Both in vivo and in vitro Hg2+ caused dose dependent inhibition of rat platelet aggregation. However, as low a dose as 88.8 pM Hg2+ could initiate ADP-induced aggregation even in the absence of added calcium. The action of Hg2+ was found to be unaffected by antagonists such as cAMP and theophylline either alone or in combination. Hg2+induced platelet aggregation was inhibited completely by pre-incubation with aspirin (1mmol·L-1), but it was ineffective when added after Hg2+. The results also indicate that the normal platelet function is affected by both high and low concentrations of Hg2+.
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