Effects of Electromagnetic Pulse on Bone Metabolism of Mice in vivo

摘要

Objective To study the effects of electromagnetic pulse(EMP) on bone metabolism of mice in vivo.Methods Twenty-four male BALB/c mice were divided into a control group and 2 experimental groups(n=8) .The whole-body of mice in experimental groups were exposed to 50 kV/m and 400kV/m EMP,400 pulses daily for 7 consecutive days at 2 seconds intervals.Alkaline phosphotase(ALP) activity,serum calcium concentration and osteocalcin level and trabecular bone volume(BV/TV,%) were measured immediately after EMP exposure by biochemical,ELISA and morphological methods.Results The ALP activity,serum calcium concentration and osteocalcin level and BV/TV in experimental groups remained unchanged after EMP exposure.Conclusion Under our experimental conditions,EMP exposure cannot affect bone metabolism of mice in vivo.