NSCL/P is a common congenital defect and gene-environmental factors involve in this disorder.Periconceptional intake of folate may reduce the risk of NSCL/P.The present study investigated three SNPs(rs1801198,rs955516,and rs3733890)in three folate pathway genes,including TCN2,MTR,and BHMT among 481 patients and 558 healthy subjects.Rs955516 showed allelic association with NSCL/P.More patients carry rs955516 AA and rs3733890
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