Up-and Down-regulated Leukemia-related Protein 16 Affects ERα Expression and Prolactin Secretion by GH3 Cells

摘要

Prolactinoma is an estrogen‐related tumor and leukemia‐related protein 16(LRP16)is correlated with the progression of estrogen‐related tumors,but the regulatory mechanism between LRP16 and prolactinoma remain unclear.This study demonstrates a variation in LRP16 with estrogen receptorα(ERα)in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells(GH_3cells).In our study,50 male SD rats(30‐day‐old)