骨髓来源免疫细胞对肿瘤血管生成的调节及临床应用研究进展

摘要

In the past years,growing evidences have shown that bone marrow-derived myeloid cells play a key role in regulating the formation of blood vessels in tumors.Myeloid cells promote tumor angiogenesis in various manners,including VEGF secretion and VEGF independent way.The latter constitutes the mechanism of tumor refractoriness to anti-VEGF therapy.Myeloid cells also promote tumor recurrence after radiotherapy or chemotherapy.Last,we discuss its concomitant therapeutic implications.%近年来研究发现髓系细胞在肿瘤血管生成中发挥关键的调控作用.髓系细胞可以通过多种途径促进血管生成,包括分泌VEGF及不依赖于VEGF的方式,后者参与介导了抗血管生成治疗中肿瘤抵抗性的形成.此外,髓系细胞还限制了放化疗的治疗效果,促进复发.最后,本文初步探讨了其临床应用前景.