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RNA in human sperm

机译:人类精子中的RNA

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摘要

We have yet to develop a fundamental understanding of the molecular complexities of human spermatozoa. This encompasses the unique packaging and structure of the sperm genome along with their paternally derived RNAs in preparation for their delivery to the egg. The diversity of these transcripts is vast, including several anti-sense molecules resembling known regulatory micro-RNAs. The field is still grasping with its delivery to the oocyte at fertilization and possible significance. It remains tempting to analogize them to maternally-derived transcripts active in early embryo patterning. Irrespective of their role in the embryo, their use as a means to assess male factor infertility is promising.
机译:我们尚未对人类精子的分子复杂性有基本的了解。这包括精子基因组的独特包装和结构,以及其父本衍生的RNA,以准备将其递送到卵中。这些转录本的多样性是巨大的,包括几个类似于已知调控微RNA的反义分子。该领域仍在掌握其受精时向卵母细胞的输送及其可能的意义。将它们与在早期胚胎模式中活跃的母本转录物进行类比仍然很诱人。不管它们在胚胎中的作用如何,将其用作评估男性因素不育的手段都是有希望的。

著录项

  • 来源
    《亚洲男性学杂志(英文版)》 |2005年第2期|115-120|共6页
  • 作者单位

    Center for Molecular Medicine and Genetics,Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA;

    Center for Molecular Medicine and Genetics,Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA;

    Department of Obstetrics and Gynecology,Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA;

    Institute for Scientific Computing,Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 基础医学;
  • 关键词

    RNA; siRNA; miRNA; sperm; microarray; fertilization; diagnostics;

    机译:RNA;siRNA;miRNA;精子;微阵列;受精;诊断;
  • 入库时间 2022-08-19 03:40:48
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