首页> 外文期刊>亚洲男性学杂志(英文版) >Induction of spermatogenesis in men with azoospermia or severe oligoteratoasthenospermia after antegrade internal spermatic vein sclerotherapy for the treatment of varicocele
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Induction of spermatogenesis in men with azoospermia or severe oligoteratoasthenospermia after antegrade internal spermatic vein sclerotherapy for the treatment of varicocele

机译:精子内静脉硬化治疗前无精子症或重度少精子症少精症男性精子发生的诱发

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摘要

Aim: To evaluate the treatment outcome of antegrade internal spermatic vein sclerotherapy in men with non-obstructive azoospermia or severe oligoteratoasthenospermia (OTA) as a result of varicocele. Methods: Between September 1995 and January 2004, 47 patients (mean age 33.8 ± 6.3 years) underwent antegrade internal spermatic vein sclerotherapy for the treatment of varicocele with azoospermia (14 patients) or severe OTA (33 patients). Testicular core biopsy was also performed in complete azoospermic patients who provided informed consent. The outcome was assessed in terms of improvement in semen parameters and conception rate. Results: Forty-two (89.4%) of 47patients had bilateral varicocele. Serum follicle stimulating hormone (FSH) did not differ between patients with azoospermia and severe OTA. After the follow-up of 24.8 ± 9.2 months, significant improvement was noted in mean sperm concentration, motility and morphology in 35 patients (74.5%). Comparison between groups during the follow-up revealed significantly higher values of sperm concentration, motility and normal morphology in the severe OTA group. Pregnancy was achieved in 14 cases (29.8%). Testicular histopathology of the azoospermic patients with postoperative induction of spermatogenesis revealed maturation arrest at spermatid stage, Sertoli-cell-only (SCO)with focal spermatogenesis or hypospermatogenesis. None of the patients with pure SCO pattern or maturation arrest at spermatocyte stage achieved spermatogenesis after the treatment. Preoperative serum FSH levels didn't relate to treatment outcome. Conclusion: Antegrade internal spermatic vein sclerotherapy is an easy and effective treatment for symptomatic varicocele. It can significantly reverse testicular dysfunction and improve spermatogenesis in men with severe OTA, as well as induce sperm production in men with azoospermia, improving pregnancy rates in subfertile couples.
机译:目的:评估无精索静脉曲张导致的非阻塞性无精子症或严重少精子症的少精子症(OTA)的男性顺行精索内静脉硬化治疗的结果。方法:在1995年9月至2004年1月之间,对47例(平均年龄33.8±6.3岁)的患者行顺行精索内静脉硬化治疗,以治疗无精索静脉曲张伴无精子症(14例)或严重OTA(33例)。在提供知情同意的完全无精子症患者中也进行了睾丸核心活检。根据精液参数和受孕率的改善对结果进行评估。结果:47例患者中有42例(89.4%)患有双侧精索静脉曲张。无精子症和重度OTA患者的血清卵泡刺激素(FSH)没有差异。在24.8±9.2个月的随访中,发现35例患者(74.5%)的平均精子浓度,运动能力和形态显着改善。随访期间各组之间的比较显示,在严重的OTA组中,精子浓度,运动力和正常形态的值显着较高。妊娠14例(29.8%)。无精子症患者术后精子发生诱导的睾丸组织病理学显示,精子成熟期停止成熟,仅局限性精原细胞生成或发育不足的Stolili-cell(SCO)。在治疗后,所有具有纯SCO模式或在精母细胞阶段成熟停滞的患者均未实现精子发生。术前血清FSH水平与治疗结果无关。结论:整合式精索内静脉硬化术是一种有症状的精索静脉曲张的简便有效的治疗方法。它可以显着逆转患有严重OTA的男性的睾丸功能障碍并改善精子生成,还可以诱导无精症男性的精子产生,从而改善不育夫妇的妊娠率。

著录项

  • 来源
    《亚洲男性学杂志(英文版)》 |2006年第5期|613-619|共7页
  • 作者单位

    Department of Urology and Pediatric Urology, Krankenhaus Nordwest, Stiftung Hospital zum Heiligen Geist Frankfurt am Main D-60488, Germany;

    Department of Urology and Pediatric Urology, Krankenhaus Nordwest, Stiftung Hospital zum Heiligen Geist Frankfurt am Main D-60488, Germany;

    Department of Urology and Pediatric Urology, Krankenhaus Nordwest, Stiftung Hospital zum Heiligen Geist Frankfurt am Main D-60488, Germany;

    Department of Urology and Pediatric Urology, Krankenhaus Nordwest, Stiftung Hospital zum Heiligen Geist Frankfurt am Main D-60488, Germany;

    Department of Urology and Pediatric Urology, Krankenhaus Nordwest, Stiftung Hospital zum Heiligen Geist Frankfurt am Main D-60488, Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 基础医学;
  • 关键词

    varicocele; oligoasthenoteratospermia; azoospermia; sclerotherapy; spermatogenesis;

    机译:varicocele;oligoasthenoteratospermia;azoospermia;硬化治疗;精子发生;
  • 入库时间 2022-08-19 03:40:48
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