Animal models are being developed for testing different vaccine candidates as well as testing of new antituber-cular since a long time.Mice,guinea pigs and rabbits are animals which are frequently used.Though each model has got its merits as well as demerits and each of them differ from human tuberculosis in one aspect or the other but none of the model completely mimics the human disease.Out of the different animal species, guinea pig model is one of the better models as it is very sensitive to M.tuberculosis infection but it has certain limitations like paucity of immunological reagents.However,it is the best model for tuberculosis research.
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