Protective effect ofLuffa acutangula extracts on gastric ulceration in NIDDM rats：Role of gastric mucosal glycoproteins and antioxidants

摘要

Objective:To study the comparative gastroprotective effect ofLuffa acutangula methanolic extract(LAM) and aqueous extract(LAW) on typeII diabetes rats.Methods:Streptozotocin(65 mg/kg,i.p.) along with nicotinamide(120 mg/kg,i.p.) was used to induce non insulin dependent diabetes mellitus(NIDDM) in rats.A daily oral dose of aspirin(200 mg/kg,i.p.) was administered for initial seven days to induce gastric ulcerations in the diabetic rats.LAM andLAW were administered orally in the doses of100,200 and400 mg/kg once daily for21 days.Glibenclamide and ranitidine were used as standards for comparing the antidiabetic and antiulcer effect respectively.Results:LAM significantly(P<0.01) increased mucosal glycoprotein and antioxidant enzyme level in gastric mucosa of diabetic rats thanLAW(P <0.05).LAM was efficient inreversing the delayed healing of gastric ulcer in diabetic rats close to the normal level.LAM exhibited better ulcer healing effect than glibenclamide andLAW, because of its both antihyperglycemic and mucosal defensive actions.Conclusions:Thus,LAM is proved to be a better alternative for treating gastric ulcers co-occurring with diabetes.