氧化法制备1，2-苯并异噻唑啉-3-酮

摘要

以二硫化二苯甲酸为起始原料，经酰胺化后以双氧水为氧化剂，制备1，2-苯并异噻唑啉-3-酮。结果表明，在氧化剂与酰胺的摩尔比为1.2：1，反应时间为3 h，反应温度60℃条件下，反应总收率可达67.7%，产物熔点156~158℃。加入催化剂三乙胺，可加速反应，使得反应时间缩短为2 h，同时氧化反应产率提高为79.2%。%1,2-Benzisothiazdin-3-one was prepared from 2,2-dithiobis-benzoic acid by acylation,oxidation with hydrogen peroxide. The result showed that the molar ratio of oxidant and amide was 1. 2: 1,the reac-tion time was 3 h,and the reaction temperature was about 60 ℃ ,and the total yield was 67. 7% ,the melt-ing point product was 156 ~ 158 ℃. The oxidation reaction time was shortened to 2 h by the catalyst tri-ethylamine,and yield of the reaction was increased to 79. 2% as well.