塞克硝唑胶囊溶出度测定方法研究

摘要

目的 建立塞克硝唑胶囊溶出度测定方法.方法 采用高效液相色谱法(HPLC)测定塞克硝唑胶囊的溶出度.溶出条件为中国药典2005年版溶出度测定法第一法,溶出介质为盐酸溶液(1→1 000).结果 绘制的溶出曲线表明45 min内塞克硝唑胶囊可溶出80%以上,确定的溶出时间为45 min,限度为80%.结论 该法快速准确,可作为塞克硝唑胶囊的质量控制方法.%Aim To establish the determination method of the dissolution test of secnidazole capsules. Method HPLC method was employed in the determination of the dissolution of secnidazole capsules. The method which was used as the dissolution conditions was the first method of the dissolution test of ChP 2005 .and the mediator was hydrochloric acid solution(1→1 000 ). Results The curve showed that secnidazole capsules can dissolve above 80％ within 45 minutes. It is comfimed that the time of dissolution was 45 minutes and thelimit was 80％ . Conclusion This method is rapid and accurate. It can be applied to determine dissolution of secnidazole capsules.