肥大细胞在免疫反应中的调节作用

摘要

Mast cells ( MC) derived from hematopoietic stem cells ,including mucosal and connective tissue MC two subsets ,can not on-ly be effector cells but as immunomodulatory cells in the body .MC may process and present antigen by MHC molecules and produce chemokines to induce T cells migration .MC have positive immunomodulatory functions by direct contact or using TNF-αand protease in the immune response,on the other hand,through the production of IL-10 and probably other products ,MC can have negative immuno-regulatory functions .%肥大细胞（ MC）起源于造血干细胞，包括黏膜MC和结缔组织MC两个亚群。机体中MC不仅可作为效应细胞，也可作为免疫调节细胞起作用。它可通过MHC分子对抗原进行加工、递呈，也可产生化学因子募集T细胞。在免疫反应中，MC一方面通过直接接触或产生的TNF-α、蛋白酶类正向调节免疫应答，另一方面也可通过分泌IL-10等分子负向调节免疫应答。