抗菌药物不合理使用导致的药物不良反应发生的相关性分析

摘要

ObjectiveToinvestigatethecorrelationofirrationalityofantibioticsuseandadversedrugreactions(ADR).Methods 200 case reports of adverse drug reactions in our hospital were analyzed retrospectively ,and the correlation of unreasonable use of antibacte-rialdrugsandallkindsofadversereactionswasanalyzedbyPearsoncorrelationanalysis.Results 100ADRcases(50.00%)(112 cases-frequencies)were induced by antibacterials.Quinolones were the most common causes of the ADR (42.86%)(48 cases-frequen-cies),followed by β-lactam antibiotics (32.14%) (36 cases-frequencies).The main parts of the ADR were skin and soft tissue (57.00%),followed by digestive system(27.00%).After Pearson correlation analysis ,extra-long administration time,extra-fast drip-ping speed,extra-high drug concentration and overdose were associated with adverse reactions significantly (P<0.05).Conclusions The main cause of adverse drug reactions is irrationality of using antibiotics .The rationality of antimicrobial usage should be further im-proved,so as to avoid ADR induced by antibacterials .%目的：探讨抗菌药物不合理使用与药物不良反应发生的相关性。方法回顾性分析该院收治的200例药物不良反应病例报告，采用Person相关性分析抗菌药物不合理使用方式与各类不良反应表现的相关性。结果抗菌药物不合理使用导致的药物不良反应患者100例（50．00％），共112例次，使用喹诺酮类药物引起不良反应最常见，构成比为42．86％（48例次），其次为β-内酰胺类抗生素，构成比为32．14％（36例次）；皮肤及软组织是不良反应发生的主要部位，构成比为（57．00％），其次为消化系统，构成比为（27．00％）；经Person相关性分析后，给药时间过长、滴速过快、药液浓度过高、剂量过大等因素，均与不良反应显著相关（ P＜0．05）。结论抗菌药物的不合理使用仍是该院引起药物不良反应的主要原因，应进一步提高抗菌药物使用的合理性，有利于降低不良反应的发生率。