不同取代度的寡聚精氨酸壳聚糖的合成与鉴定

摘要

Objective To synthesize chitosan modified nonaarginine (CS-R9) with different degrees of substitution (DS) and to char-acterize the structure and DS by FTIR and 1H-NMR.Methods R9 and CS with high molecular weight ( HCS) or low molecular weight (LCS) as the raw materials,a series of CS-R9 with different DS were synthesized by changing the mole ratio between them .The struc-ture and DS of CS-R9 was characterized by FTIR and 1 HNMR.Results A series of CS-R9 was synthesized including HCS-R9 with the DS of 0.96 and 1.87,LCS-R9 with the DS of 2.61 and 10.10,respectively.Conclusions CS-R9 with different DS was synthesized successfully ,which provides the basis for the further studies .%目的：合成不同分子量、不同取代度的寡聚精氨酸壳聚糖（ CS-PR），并对其化学结构及取代度进行鉴定。方法用高分子量壳聚糖（HCS）、低分子量壳聚糖（LCS）和寡聚精氨酸（R9）为主要原料，通过改变反应物的摩尔比，合成不同取代度CS-PR，应用FTIR及1 H-NMR对其结构及取代度进行分析。结果通过改变反应物的摩尔比，获得了取代度为0．96和1．87的HCS-R9，以及取代度为2．61和10．10的LCS-R9。结论不同分子量不同取代度的CS-PR合成成功，为进一步实验奠定了基础。