多烯磷脂酰胆碱联合维生素E对非酒精性脂肪性肝炎合并2型糖尿病患者的治疗效果

摘要

Objective To investigate the clinical efficacy of polyene phosphatidylcholine combined with vitamin E in patients with nonalcoholic steatohepatitis combined with type 2 diabetes.Methods Eighty-four patients of nonalcoholic fatty hepatitis with type 2 diabetes were chosen as the research objects,and randomly assigned into control group (42 cases) and test group (42 cases).The control group was given polyene phosphatidylcholine treatment,while the test group was given polyene phosphatidylcholine and vitamin E capsules treatment.Two months after the treatment,blood glucose levels,liver function indicators and the degree of fatty liver of the patients were tested and the efficacy of the treatment was analyzed.Results After 2-month treatment,the total effective rate of the test group was 78.57％,significantly higher than that of the control group (54.76％,x2 =5.357,P =0.021).Blood glucose in the control group and the test group were lower than before treatment,and the difference was statistically significant (P ＜ 0.05);but there was no statistically significant difference in blood glucose of the two groups before and after treatment (P ＞ 0.05).After treatment,the levels of ALT,AST,TG and TC in the test group were significantly lower than those of the control group;the differences were statistically significant (P ＜ 0.05).The liver B-ultrasound score of the test group was significantly lower than that of the control group (P ＜ 0.05).Conclusions Polyene phosphatidylcholine combined with vitamin E has a better therapeutic effect on nonalcoholic steatohepatitis and type 2 diabetes mellitus,which can improve liver function and reduce the degree of steatosis.%目的 探讨多烯磷脂酰胆碱联合维生素E对非酒精性脂肪性肝炎合并2型糖尿病患者的临床疗效.方法 选择84例非酒精性脂肪性肝炎合并2型糖尿病患者为对象,按照随机数字表法分为对照组和观察组,每组42例,对照组给予多烯磷脂酰胆碱治疗,观察组给予多烯磷脂酰胆碱和维生素E胶丸治疗.2个月后观察患者疗效,检测血糖水平、肝功能指标和脂肪肝的程度.结果 治疗2个月后,观察组的总有效率(78.57％)高于对照组(54.76％),差异有统计学意义(x2=5.357,P=0.021).对照组和观察组血糖均低于治疗前,差异有统计学意义(P＜0.05);但治疗前后两组患者血糖比较,差异无统计学意义(P＞0.05).治疗后观察组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、三酰甘油(TG)和总胆固醇(TC)均明显低于对照组,差异有统计学意义(P＜0.05).观察组肝脏B超评分明显低于对照组,差异有统计学意义(P＜0.05).结论 多烯磷脂酰胆碱联合维生素E对非酒精性脂肪性肝炎合并2型糖尿病患者具有较好的治疗效果,可改善肝功能,降低脂肪化程度.