溺水引发吸入性肺炎病人使用抗感染药物致药物性肝损伤的药学监护1例分析

摘要

目的 探讨1例溺水引发吸入性肺炎病人使用抗感染药物致药物性肝损伤治疗实践.方法 临床药师参与呼吸科重症监护室(ICU)抗感染药物治疗,对抗菌药物的选择、药物相互作用和不良反应监测等方面提出合理的建议.结果 临床药师采用计算推算法(法国归因系统)评定该例肝损伤病人的可疑药物不良反应的等级,对可疑药物提供血药浓度监测(TDM),为诊断药物性肝损伤提供依据.结论 药学监护可以减少药物不良反应的发生,提高药物治疗的安全性和有效性.%Objective To explore clinical pharmacists participating in drug-induced liver injury treatment practice for 1 patient after drowning.Methods Clinical pharmacists participating in anti-infection therapy in respiratory intensive care unit (ICU),including the choice of antimicrobial drugs,drug interactions and monitoring of adverse reactions.Results Clinical pharmacists use the method of Calculation Method (French Attribution System) to assess the level of suspicious adverse drug reactions in patients with liver injury.Meanwhile,clinical pharmacists should perform blood concentration monitoring(TDM)to provide positive evidence for the diagnosis of drug induced liver injury.Conclusions Pharmaceutical care can reduce the adverse reaction and improve safety and efficacy of treatment.